منابع مشابه
Robustness as an evolutionary principle.
We suggest simulating evolution of complex organisms using a model constrained solely by the requirement of robustness in its expression patterns. This scenario is illustrated by evolving discrete logical networks with epigenetic properties. Evidence for dynamical features in the evolved networks is found that can be related to biological observables.
متن کاملGround State Robustness as an Evolutionary Design Principle in Signaling Networks
The ability of an organism to survive depends on its capability to adapt to external conditions. In addition to metabolic versatility and efficient replication, reliable signal transduction is essential. As signaling systems are under permanent evolutionary pressure one may assume that their structure reflects certain functional properties. However, despite promising theoretical studies in rece...
متن کاملRobustness and network evolution—an entropic principle
This article introduces the concept of network entropy as a characteristic measure of network topology. We provide computational and analytical support for the hypothesis that network entropy is a quantitative measure of robustness. We formulate an evolutionary model based on entropy as a selective criterion and show that (a) it predicts the direction of changes in network structure over evolut...
متن کاملEvolutionary Trade-offs as a Central Organizing Principle in Biology
................................................................................................................viii
متن کاملGenetic Code Evolution Reveals the Neutral Emergence of Mutational Robustness, and Information as an Evolutionary Constraint
The standard genetic code (SGC) is central to molecular biology and its origin and evolution is a fundamental problem in evolutionary biology, the elucidation of which promises to reveal much about the origins of life. In addition, we propose that study of its origin can also reveal some fundamental and generalizable insights into mechanisms of molecular evolution, utilizing concepts from compl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the Royal Society of London. Series B: Biological Sciences
سال: 2000
ISSN: 0962-8452,1471-2954
DOI: 10.1098/rspb.2000.1280